MZ 1
- Product Name
- MZ 1
- CAS No.
- 1797406-69-9
- Chemical Name
- MZ 1
- Synonyms
- MZ 1;MZ-1;MZ 1;cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit;L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- CBNumber
- CB53367716
- Molecular Formula
- C49H60ClN9O8S2
- Formula Weight
- 1002.64
- MOL File
- 1797406-69-9.mol
MZ 1 Property
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO:30.0(Max Conc. mg/mL);29.9(Max Conc. mM)
- form
- A crystalline solid
- pka
- 13.54±0.46(Predicted)
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML3365
- Product name
- MZ1
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $114
- Updated
- 2024/03/01
- Product number
- SML3365
- Product name
- MZ1
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $457
- Updated
- 2024/03/01
- Product number
- 21622
- Product name
- MZ1
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 21622
- Product name
- MZ1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 21622
- Product name
- MZ1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $393
- Updated
- 2024/03/01
MZ 1 Chemical Properties,Usage,Production
Description
MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 μM. At concentrations of 2-10 μM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.
Uses
MZ 1, is a BRD4 protein degrader based on PROTAC technology. The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1.
Definition
ChEBI: MZ1 is an organic molecular entity.
storage
Store at -20°C
MZ 1 Preparation Products And Raw materials
Raw materials
Preparation Products
MZ 1 Suppliers
View Lastest Price from MZ 1 manufacturers
- Product
- MZ 1 1797406-69-9
- Price
- US $0.00/mg
- Min. Order
- 1mg
- Purity
- 98%min
- Supply Ability
- 500mg
- Release date
- 2021-08-26